Blue Cross/Blue Shield and other commercial payers develop S codes to report drugs, services, and supplies. These codes may not be used to bill services paid under any Medicare payment system. Medicare does not reimburse for services under S codes.

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• S5160

  Emergency response system; installation and testing

• S5161

  Emergency response system; service fee, per month (excludes installation and testing)

• S5162

  Emergency response system; purchase only

• S5165

  Home modifications; per service

• S5170

  Home delivered meals, including preparation; per meal

• S5175

  Laundry service, external, professional; per order

• S5180

  Home health respiratory therapy, initial evaluation

• S5181

  Home health respiratory therapy, nos, per diem

• S5185

  Medication reminder service, non-face-to-face; per month

• S5190

  Wellness assessment, performed by non-physician

• S5199

  Personal care item, nos, each

• S5497

  Home infusion therapy, catheter care / maintenance, not otherwise classified; includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem

• S5498

  Home infusion therapy, catheter care / maintenance, simple (single lumen), includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem

• S5501

  Home infusion therapy, catheter care / maintenance, complex (more than one lumen), includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem

• S5502

  Home infusion therapy, catheter care / maintenance, implanted access device, includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem (use this code for interim maintenance of vascular access not currently in use)

• S5517

  Home infusion therapy, all supplies necessary for restoration of catheter patency or declotting

• S5518

  Home infusion therapy, all supplies necessary for catheter repair

• S5520

  Home infusion therapy, all supplies (including catheter) necessary for a peripherally inserted central venous catheter (picc) line insertion

• S5521

  Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion

• S5522

  Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)

• S5523

  Home infusion therapy, insertion of midline venous catheter, nursing services only (no supplies or catheter included)

• S5550

  Insulin, rapid onset, 5 units

• S5551

  Insulin, most rapid onset (lispro or aspart); 5 units

• S5552

  Insulin, intermediate acting (nph or lente); 5 units

• S5553

  Insulin, long acting; 5 units

• S5560

  Insulin delivery device, reusable pen; 1.5 ml size

• S5561

  Insulin delivery device, reusable pen; 3 ml size

• S5565

  Insulin cartridge for use in insulin delivery device other than pump; 150 units

• S5566

  Insulin cartridge for use in insulin delivery device other than pump; 300 units

• S5570

  Insulin delivery device, disposable pen (including insulin); 1.5 ml size

• S5571

  Insulin delivery device, disposable pen (including insulin); 3 ml size

• S8030

  Scleral application of tantalum ring(s) for localization of lesions for proton beam therapy

• S8032

  Low-dose computed tomography for lung cancer screening

• S8035

  Magnetic source imaging

• S8037

  Magnetic resonance cholangiopancreatography (mrcp)

• S8040

  Topographic brain mapping

• S8042

  Magnetic resonance imaging (mri), low-field

• S8055

  Ultrasound guidance for multifetal pregnancy reduction(s), technical component (only to be used when the physician doing the reduction procedure does not perform the ultrasound, guidance is included in the cpt code for multifetal pregnancy reduction - 59866)

• S8080

  Scintimammography (radioimmunoscintigraphy of the breast), unilateral, including supply of radiopharmaceutical

• S8085

  Fluorine-18 fluorodeoxyglucose (f-18 fdg) imaging using dual-head coincidence detection system (non-dedicated pet scan)

• S8092

  Electron beam computed tomography (also known as ultrafast ct, cine ct)

• S8096

  Portable peak flow meter

• S8097

  Asthma kit (including but not limited to portable peak expiratory flow meter, instructional video, brochure, and/or spacer)

• S8100

  Holding chamber or spacer for use with an inhaler or nebulizer; without mask

• S8101

  Holding chamber or spacer for use with an inhaler or nebulizer; with mask

• S8110

  Peak expiratory flow rate (physician services)

• S8120

  Oxygen contents, gaseous, 1 unit equals 1 cubic foot

• S8121

  Oxygen contents, liquid, 1 unit equals 1 pound

• S8130

  Interferential current stimulator, 2 channel

• S8131

  Interferential current stimulator, 4 channel

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HCPCS Level II codes and descriptors are approved and maintained jointly by the alpha-numeric editorial panel (consisting of CMS, the Health Insurance Association of America, and the Blue Cross and Blue Shield Association). — Updated 6/3/2026

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