Blue Cross/Blue Shield and other commercial payers develop S codes to report drugs, services, and supplies. These codes may not be used to bill services paid under any Medicare payment system. Medicare does not reimburse for services under S codes.
S0354S0390S0395S0400S0500S0504S0506S0508S0510S0512S0514S0515S0516S0518S0580S0581S0590S0592S0595S0596S0601S0610S0612S0613S0618S0620S0621S0622S0630S0800S0810S0812S1001S1002S1015S1016S1030S1031S1034S1035S1036S1037S1040S1090S1091S2053S2054S2055S2060S2061HCPCS Level II codes and descriptors are approved and maintained jointly by the alpha-numeric editorial panel (consisting of CMS, the Health Insurance Association of America, and the Blue Cross and Blue Shield Association). — Updated 7/24/2026
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