Blue Cross/Blue Shield and other commercial payers develop S codes to report drugs, services, and supplies. These codes may not be used to bill services paid under any Medicare payment system. Medicare does not reimburse for services under S codes.
S2065S2066S2067S2068S2070S2079S2080S2083S2095S2102S2103S2107S2112S2115S2117S2118S2120S2140S2142S2150S2152S2202S2205S2206S2207S2208S2209S2225S2230S2235S2260S2265S2266S2267S2300S2325S2340S2341S2342S2348S2350S2351S2360S2361S2400S2401S2402S2403S2404S2405HCPCS Level II codes and descriptors are approved and maintained jointly by the alpha-numeric editorial panel (consisting of CMS, the Health Insurance Association of America, and the Blue Cross and Blue Shield Association). — Updated 7/24/2026
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